Hopkins began his NHS journey at Addenbrooke's Hospital in 1985, progressing through clinical and management roles before becoming chief executive. His career has spanned both frontline patient care and senior leadership positions.

He said: ‘This decision marks the end of an incredible professional journey, but the beginning of an important personal one. My wife's recent cancer diagnosis and treatment has reminded us both of the patient perspective and the importance of family time. As she continues her recovery, we plan to work together on initiatives to improve cancer pathways for other families.'

Dr Andy Wood, chair of the trust, said: ‘Matthew has made a significant contribution to the NHS during his career. We understand and fully support his decision to prioritise his family at this important time. We are committed to ensuring a smooth transition and will be announcing succession arrangements in due course. I am sure everyone will join me in thanking Matthew for his dedicated service.'

Hopkins will remain in post until November to ensure continuity of leadership.