NHS rolls out 'trojan horse' therapy for blood cancer patients

A ‘trojan horse’ therapy for blood cancer patients is being rolled out by the NHS in England in a ‘world first’.

(c) National Cancer Institute/Unsplash

(c) National Cancer Institute/Unsplash

Around 1,500 patients a year with multiple myeloma – an incurable cancer of the bone marrow – could now be offered belantamab mafodotin, after it was approved by NICE on 12 June.

Health minister, Karin Smyth, said: ‘This groundbreaking therapy puts the NHS at the forefront of cancer innovation. By harnessing cutting-edge 'trojan horse' technology, we're offering new hope to blood cancer patients across the country.'

The drug will be offered to eligible patients whose cancer has progressed or not responded to first-line treatment with another drug, lenalidomide.

The drugs have been described by researchers as ‘trojan horses' as they are designed to be taken up by the cancer cell, before releasing a high concentration of a lethal molecule to destroy the cell from within.

Trials showed that in a broader group of patients with relapsed or refractory multiple myeloma, belantamab mafodotin (in combination with bortezomib and dexamethasone) delayed progression of the disease by an average of three years, compared to just over a year for patients taking commonly-used drug daratumumab (with bortezomib and dexamethasone).

NHS England is fast-tracking access to the treatment for patients from today, through immediate funding via the Cancer Drugs Fund.

Eligible patients will be treated via an infusion every three weeks in combination with other cancer drugs, bortezomib (injection) and dexamethasone (orally).

Each year, more than 6,000 people are diagnosed with multiple myeloma in the UK, and it is estimated there are around 33,000 people living with the cancer.

Red tape blocking access to cutting edge cancer treatments, say doctors

Red tape blocking access to cutting edge cancer treatments, say doctors

By Lee Peart 11 September 2025

Patient access to cutting edge cancer treatments is being blocked by current commissioning and funding structures, doctors have warned.

HRH The Duke of Edinburgh opens cancer treatment suite

By Lee Peart 08 September 2025

HRH The Duke of Edinburgh has opened a suite to support the treatment of gynaecological cancers at the University Hospitals of Leicester NHS Trust’s (UHL) Le...

Next-gen therapies for cancer and dementia fast-tracked with new facility

By Liz Wells 28 August 2025

The UK government is to invest £29.6m in a new facility that will springboard new RNA therapies, which could help tackle cancer, heart conditions, and other ...


Popular articles by Lee Peart