NHS rolls out 'trojan horse' therapy for blood cancer patients

A ‘trojan horse’ therapy for blood cancer patients is being rolled out by the NHS in England in a ‘world first’.

(c) National Cancer Institute/Unsplash

(c) National Cancer Institute/Unsplash

Around 1,500 patients a year with multiple myeloma – an incurable cancer of the bone marrow – could now be offered belantamab mafodotin, after it was approved by NICE on 12 June.

Health minister, Karin Smyth, said: ‘This groundbreaking therapy puts the NHS at the forefront of cancer innovation. By harnessing cutting-edge 'trojan horse' technology, we're offering new hope to blood cancer patients across the country.'

The drug will be offered to eligible patients whose cancer has progressed or not responded to first-line treatment with another drug, lenalidomide.

The drugs have been described by researchers as ‘trojan horses' as they are designed to be taken up by the cancer cell, before releasing a high concentration of a lethal molecule to destroy the cell from within.

Trials showed that in a broader group of patients with relapsed or refractory multiple myeloma, belantamab mafodotin (in combination with bortezomib and dexamethasone) delayed progression of the disease by an average of three years, compared to just over a year for patients taking commonly-used drug daratumumab (with bortezomib and dexamethasone).

NHS England is fast-tracking access to the treatment for patients from today, through immediate funding via the Cancer Drugs Fund.

Eligible patients will be treated via an infusion every three weeks in combination with other cancer drugs, bortezomib (injection) and dexamethasone (orally).

Each year, more than 6,000 people are diagnosed with multiple myeloma in the UK, and it is estimated there are around 33,000 people living with the cancer.

BMA urged to consider patients and staff before calling more walk-outs

BMA urged to consider patients and staff before calling more walk-outs

By Liz Wells 30 July 2025

NHS leaders are urging BMA to consider patients and staff before calling more strike action.

Thousands urged to get lifesaving cancer vaccine

By Lee Peart 21 July 2025

Hundreds of thousands of people are being urged to have the lifesaving human papillomavirus (HPV) vaccine to protect against cervical and other cancers.

Families and carers more involved in cancer care, survey finds

By Lee Peart 17 July 2025

Families and carers are more involved in cancer care but less than half of patients (47.7%) are satisfied with their level of GP support, according to a surv...


Popular articles by Lee Peart