PATH brings together leading technology companies General Catalyst, NVIDIA, Hippocratic AI, and Sword Health to explore comprehensive solutions to deliver the NHS's vision of the three shifts.

Through harnessing frontier machine learning and agentic AI technologies, PATH aims to transform NHS care delivery, enabling a more proactive, coordinated, and efficient health system, and laying the foundation for a scalable, national model of population health.

PATH combines:

• Guy's and St Thomas' Centre of Innovation, Transformation, and Improvement (CITI), with its mission to support the Trust to deliver better, faster, fairer healthcare
• Hippocratic AI's Safety-focused Generative AI Healthcare Agents, powered by its clinically proven and patented Polaris safety constellation architecture, conduct non-diagnostic patient-facing outreach. To date, more than 2.49 million patient calls have been made with a high average patient satisfaction rating of 8.95/10
• Sword Health's AI Care platform has already treated over 500,000 patients globally across physical pain, pelvic health, and other clinical areas, delivering 6.5 million AI sessions to date and saving nearly $1 billion in unnecessary healthcare costs
• NVIDIA Inception for startups, including technical tools and training for AI developers, preferred pricing on NVIDIA hardware and software, and opportunities to connect with NVIDIA's network of venture capital firms
• General Catalyst's health system expertise to identify transformative technology providers and align incentives through shared-savings models that drive measurable impact.

PATH will first target one of the trust's most urgent challenges - the elective care waiting list. At Guy's and St Thomas' alone, more than 53,000 patients are waiting for a first appointment, and 25,000 are awaiting surgery.

The initiative will explore end-to-end solutions that go further than just managing waiting lists - it aims to transform the patient journey entirely. Through integrating AI-powered patient support, remote monitoring, and virtual care technologies, PATH will enable Guy's and St Thomas' clinicians to prioritise cases based on clinical need, help patients become active participants in their care, and ensure resources are allocated efficiently across the system.

Dr Nadine Hachach-Haram, clinical lead for innovation at Guy's and St Thomas', said: ‘This is a first for the NHS - rethinking pathways end-to-end with AI at the centre, from referral to recovery. We're aiming not just to treat more patients, but to treat them better.'

Howard Wright, vice-president of startup ecosystem at NVIDIA, added: ‘AI is driving a new era in healthcare that is smart, fast, and even more patient-centric. This collaboration helps build upon the transformative impact that innovative startups can have when advanced AI is harnessed to serve public health.'