First daily pill for endometriosis approved for NHS use

NICE has recommended the first long-term daily pill to treat endometriosis that could transform how the painful condition is managed.

© Danilo Alvesd/Unsplash

© Danilo Alvesd/Unsplash

The treatment, called relugolix–estradiol–norethisterone - also known as relugolix combination therapy or Ryeqo, works by blocking specific hormones that contribute to endometriosis, while also providing necessary hormone replacement in a single daily tablet.

Around 1,000 women per year with endometriosis could benefit from this new treatment that:

  • Starts working more quickly than injectable alternatives
  • Can be taken at home rather than at clinics
  • Combines all needed hormones in one pill
  • Returns hormone levels to normal faster when stopped.

Helen Knight, our director of medicines evaluation, said: ‘This new treatment marks a potential step-change in how we manage endometriosis, putting control back in patients' hands while ensuring value for the taxpayer.'

She added: ‘Instead of travelling to clinics for injections, there is now a daily tablet that can be taken at home. The treatment can also be stopped and started more easily, which is particularly important for those planning to have children and for managing side effects.'

The treatment will be available through routine NHS commissioning for patients for whom medical or surgical treatment for endometriosis has failed.

THE BIG INTERVIEW: Speaking with one voice

THE BIG INTERVIEW: Speaking with one voice

By Lee Peart 17 July 2026

With this year’s passage of the Health Bill and ongoing implementation of the 10-Year Health Plan, chair of The NHS Alliance, Lord Adebowale, says there has ...

How the humble appraisal could unlock NHS-wide transformation

16 July 2026

Dr Patrick Doyle, consultant anaesthetist at Imperial College Healthcare NHS Foundation Trust and Founder of L2P (acquired by Patchwork Health), says the ann...

Private lessons

16 July 2026

John Fairhurst, chief clinical officer, Signature Clinic, explains what the private sector has learned about patient experience that the NHS cannot afford to...


Popular articles by Liz Wells