The Generation Study at St Michael's Hospital, University Hospitals Bristol and Weston NHS Foundation Trust (UHBW) and Southmead Hospital, North Bristol NHS Trust (NBT), is part of a nationwide effort to sequence the genomes of 100,000 newborn babies.

St Michael's Hospital made history as the first site in England to recruit families and complete testing for the Generation Study, beginning in October 2024. The study is led locally by Dr Tracie Miles and Dr Caroline Platt at UHBW, alongside Dr Christy Burden at NBT.

The Generation Study is led by Genomics England in partnership with NHS England. It involves collecting a small blood sample from the umbilical cord shortly after birth for whole genome sequencing. Participation is entirely voluntary and so far, more than 40,000 women across the country have signed up to the study.